Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held.

@article{Kochubey2009DevelopmentalRO,
  title={Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held.},
  author={Olexiy Kochubey and Yunyun Han and Ralf Schneggenburger},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 12},
  pages={3009-23}
}
Developmental refinement of synaptic transmission can occur via changes in several pre- and postsynaptic factors, but it has been unknown whether the intrinsic Ca2+ sensitivity of vesicle fusion in the nerve terminal can be regulated during development. Using the calyx of Held, a giant synapse in the auditory pathway, we studied the presynaptic mechanisms underlying the developmental regulation of Ca2+-secretion coupling, comparing a time period before, and shortly after the onset of hearing in… CONTINUE READING

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