Developmental regulation of the human relaxin genes in the decidua and placenta: overexpression in the preterm premature rupture of the fetal membranes.

@article{Bogic1997DevelopmentalRO,
  title={Developmental regulation of the human relaxin genes in the decidua and placenta: overexpression in the preterm premature rupture of the fetal membranes.},
  author={Ljubica Bogic and Sandra Y Yamamoto and Lynnae K Millar and Gillian D Bryant-Greenwood},
  journal={Biology of reproduction},
  year={1997},
  volume={57 4},
  pages={908-20}
}
The decidua and placenta synthesize the human relaxins, termed H1 and H2, believed to be involved in collagen remodeling in the amnion and chorion in an autocrine/paracrine manner. The developmental regulation of the relaxin genes was quantitated in normal pregnancy by in situ hybridization histochemistry with six 48-mer oligonucleotide probes that detect both relaxin genes. A significant increase in relaxin expression occurred in both decidua (p < 0.01) and placenta (p < 0.05) at 12.5-14.4 wk… CONTINUE READING