Developmental regulation of the distribution of rat brain insulin-insensitive (Glut 1) glucose transporter.

@article{Devaskar1991DevelopmentalRO,
  title={Developmental regulation of the distribution of rat brain insulin-insensitive (Glut 1) glucose transporter.},
  author={Sherin U. Devaskar and Daniel S Zahm and Lynne A. Holtzclaw and K Chundu and Brian E. Wadzinski},
  journal={Endocrinology},
  year={1991},
  volume={129 3},
  pages={1530-40}
}
We examined the immunohistochemical localization of Glut 1 in sections of developing rat brain [gestational (G) days 18 and 20, postnatal (P) days 1, 10, 21, and greater than 40; term = approximately G21] and characterized the abundance of Glut 1 in isolated brain microvessels by Western blot analysis. Further quantitation of total glucose transporters by [125I]3-iodo-4-azido-phenethyl-amido-7-O-succinyldeacetyl-forskoli n photoaffinity labeling was performed. Glut 1 was prominently distributed… CONTINUE READING