Developmental regulation of the brain polyamine-stress-response

  title={Developmental regulation of the brain polyamine-stress-response},
  author={Gad M. Gilad and Varda H. Gilad and Y Eliyayev and Jos{\'e} Martin Rabey},
  journal={International Journal of Developmental Neuroscience},
A transient increase in brain polyamine metabolism, termed the polyamine-stress-response is a common response to stressful stimuli. Previous studies have implicated an over-reactive polyamine response as a component of the maladaptive brain response to stressful events, and as a novel molecular mechanism involved in the pathophysiology of affective disorders. Ample evidence indicates that stressful experiences during early life can alter normal developmental processes and may result in… CONTINUE READING


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