Developmental regulation of spontaneous activity in the Mammalian cochlea.

@article{Tritsch2010DevelopmentalRO,
  title={Developmental regulation of spontaneous activity in the Mammalian cochlea.},
  author={Nicolas Xavier Tritsch and Dwight E Bergles},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 4},
  pages={
          1539-50
        }
}
Neurons in the developing auditory system fire bursts of action potentials before the onset of hearing. This spontaneous activity promotes the survival and maturation of auditory neurons and the refinement of synaptic connections in auditory nuclei; however, the mechanisms responsible for initiating this activity remain uncertain. Previous studies indicate that inner supporting cells (ISCs) in the developing cochlea periodically release ATP, which depolarizes inner hair cells (IHCs), leading to… CONTINUE READING

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Synaptic inputs drive bursts of action potentials in the rat auditory brainstem before the onset of hearing

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