Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.

@article{Velkov1996DevelopmentalRO,
  title={Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.},
  author={Jana Vel{\'i}{\vs}kov{\'a} and Libor Vel{\'i}{\vs}ek and Magda Lahorgue Nunes and Solomon L Mosh{\'e}},
  journal={European journal of pharmacology},
  year={1996},
  volume={309 2},
  pages={167-73}
}
GABAergic (gamma-aminobutyric acid) transmission in the substantia nigra pars reticulata is critical for seizure control. We tested the hypothesis that there is a differential regional distribution and functionality of nigral GABAA receptor sites that is developmentally regulated. In adult rats, we determined the effects on flurothyl seizures of (Z)-3-[(aminoiminomethyl)thio]prop-2-enoic acid (ZAPA, a presumed agonist of the low-affinity GABAA receptor site), bicuculline (an antagonist of the… CONTINUE READING
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