Developmental regulation of glutamate receptor field size by nonvesicular glutamate release

  title={Developmental regulation of glutamate receptor field size by nonvesicular glutamate release},
  author={David E Featherstone and Emma Rushton and Kendal Broadie},
  journal={Nature Neuroscience},
We hypothesized that presynaptic glutamate regulates postsynaptic ionotropic glutamate receptor number during synaptogenesis. To test this idea, we genetically manipulated presynaptic glutamate levels at the glutamatergic Drosophila neuromuscular junction (NMJ), then microscopically and electrophysiologically measured postsynaptic glutamate receptor field size and function. Our data show that presynaptic glutamate is a strong negative regulator of postsynaptic receptor field size and function… CONTINUE READING

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