Developmental regulation of glial cell phagocytic function during Drosophila embryogenesis.

@article{Shklyar2014DevelopmentalRO,
  title={Developmental regulation of glial cell phagocytic function during Drosophila embryogenesis.},
  author={Boris Shklyar and Yael Sellman and Jeny Shklover and Ketty Mishnaevski and Flonia Levy-Adam and Estee Kurant},
  journal={Developmental biology},
  year={2014},
  volume={393 2},
  pages={255-269}
}
The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial proficiency to phagocytose relies on expression of phagocytic receptors for apoptotic cells, SIMU and DRPR. Moreover, we reveal that the phagocytic ability of embryonic glia is… CONTINUE READING