Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

@article{Kearse1994DevelopmentalRO,
  title={Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.},
  author={Kelly P. Kearse and Joseph L. Roberts and Terry I. Munitz and David L Wiest and Toshinori Nakayama and Alfred Singer},
  journal={The EMBO journal},
  year={1994},
  volume={13 19},
  pages={4504-14}
}
The alpha beta T cell antigen receptor (TCR) that is expressed on most T lymphocytes is a multisubunit transmembrane complex composed of at least six different proteins (alpha, beta, gamma, delta, epsilon and zeta) that are assembled in the endoplasmic reticulum (ER) and then transported to the plasma membrane. Expression of the TCR complex is quantitatively regulated during T cell development, with immature CD4+CD8+ thymocytes expressing only 10% of the number of surface alpha beta TCR… CONTINUE READING

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