Developmental regulation of Ubc9 in the rat nervous system.

@article{Watanabe2008DevelopmentalRO,
  title={Developmental regulation of Ubc9 in the rat nervous system.},
  author={Mutsufusa Watanabe and Kaoru Takahashi and Kayoko Tomizawa and Hidehiro Mizusawa and Hiroshi Takahashi},
  journal={Acta biochimica Polonica},
  year={2008},
  volume={55 4},
  pages={
          681-6
        }
}
The SUMO-conjugating enzyme Ubc9 is an essential enzyme in the SUMO (small ubiquitin-related modifier) protein modification system. Although sumoylation, covalent modification of cellular proteins by SUMO, is considered to regulate various cellular processes, and many substrates for sumoylation have been identified recently, the regulation of Ubc9 expression has not been examined in detail. We analyzed the expression of Ubc9 during rat brain development at the mRNA and protein levels. Northern… CONTINUE READING

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