Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse

@article{Hestrin1992DevelopmentalRO,
  title={Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse},
  author={Shaul Hestrin},
  journal={Nature},
  year={1992},
  volume={357},
  pages={686-689}
}
THE central nervous system has extraordinary plasticity in early life. This is thought to involve N-methyl-D-aspartate (NMDA) receptors1 which, along with the non-NMDA receptors, mediate fast excitatory synaptic transmission2. Although NMDA receptors may be transiently enhanced early in life3–6, it has not been possible to demonstrate directly a functional change in the NMDA receptor-mediated synaptic response because of the voltage-dependence of the NMDA conductance and the overlapping… CONTINUE READING
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