Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster

@inproceedings{VillarGarea2012DevelopmentalRO,
  title={Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster},
  author={Ana Villar-Garea and Ignasi Forne and Irene Vetter and Elisabeth Kremmer and Andreas W Thomae and Axel Imhof},
  booktitle={Nucleic acids research},
  year={2012}
}
Histone post-translational modifications play an important role in regulating chromatin structure and gene expression in vivo. Extensive studies investigated the post-translational modifications of the core histones H3 and H4 or the linker histone H1. Much less is known on the regulation of H2A and H2B modifications. Here, we show that a major modification of H2B in Drosophila melanogaster is the methylation of the N-terminal proline, which increases during fly development. Experiments… CONTINUE READING

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