Developmental psychopathology and neurobiology of aggression

  title={Developmental psychopathology and neurobiology of aggression},
  author={Jackie K. Gollan and Royce J. Lee and Emil F. Coccaro},
  journal={Development and Psychopathology},
  pages={1151 - 1171}
The aim of this paper is to clarify how neural mechanisms at the molecular level, specifically the serotonergic (5-HT) system and the hypothalamic–pituitary–adrenal axis system (HPA) in conjunction with early life stress may contribute to the emergence of aggression, self-directed and otherwise, in borderline personality disorder (BPD). Chronic dysregulation of these biological systems, which function to regulate stress and emotion, may potentiate the development of impulsive aggression in… 
A Developmental Psychopathology and Neurobiological Model of Borderline Personality Disorder in Adolescence
The antecedents and risk factors and for developing borderline personality disorder (BPD) are now well documented, but there is a paucity of developmental models to understand the key processes
The Psychopharmacology of Aggressive Behavior: A Translational Approach Part 1 Neurobiology
The neurobiological mechanism of aggression is important to understand the rationale for using atypical antipsychotics, anticonvulsants, and lithium in treating aggressive behavior, and further research is necessary to establish how these neurotransmitter systems interact with brain circuits to control aggressive behavior at the intracellular level.
Aggression in borderline personality disorder: A multidimensional model.
These biobehavioral dimensions can be nicely linked to conceptual terms of the alternative Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) model of BPD, and thus to a multidimensional rather than a traditional categorical approach.
Neurobiological and Psychopathological Variables Related to Emotional Instability: A Study of Their Capability to Discriminate Patients with Bulimia Nervosa from Healthy Controls
The results suggest that hypothalamic-pituitary-adrenal axis activity, dopamine activity and other biological parameters are worthy of further study as potential dimensional markers of BN, although they seem to depend on the psychopathological status of the patients.
Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors
Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism, that determine the developmental trajectory of complex behaviors.
[Neurobiological aspects of reactive and proactive violence in antisocial personality disorder and "psychopathy"].
Impulsive-reactive violent offenders show increased autonomic activity in response to negative emotional and threatening stimuli and proactive-instrumental violent offenders with psychopathy demonstrate an autonomic hypo-responsivity as well as dysfunctions of the amygdala and of cortical regions related to empathic and social behavior.
Infusing Neuroscience Into the Study and Prevention of Drug Misuse and Co-Occurring Aggressive Behavior
Prevention research is beginning to focus on perturbations in developmental neural plasticity during childhood that increase the likelihood of risky behaviors and may also moderate intervention effects on behavior.
Antidepressants in the treatment of borderline personality disorder: a review of literature data
Summary Background Borderline personality disorder (BPD) is a pervasive pattern of instability of interpersonal relationships, affects and identity, as well as poorly controlled impulsivity. BPD
Alcohol, Aggression, and Violence: From Public Health to Neuroscience
Investigation into comorbidity of personality or mood disorders, state of the mind during alcohol consumption, types of beverages, environmental trigger, neurochemical changes, and gender differences that influence individual responses to alcohol intake and susceptibility to intoxicated aggression are looked into.


An integrative approach to the neurophysiological substrates of social withdrawal and aggression
An integrative model of the neurophysiology of aggression and social withdrawal is proposed and it is suggested that future research should focus on the mapping of distinct integrative biosocial profiles that are related to specific behaviors during different developmental stages.
[Enhanced suppression of cortisol after dexamethasone in borderline personality disorder. A pilot study].
BPD could be associated with hypersensitivity of feedback mechanisms of the HPA axis similar to PSD, which suggests a possible role for traumatic experiences in the pathogenesis of the disorder.
Mean genes and the biology of aggression: a critical review of recent animal and human research.
An association between low 5-HIAA levels and psychiatric disorders is confirmed, but the results fail to support any specific relationship between low 4-hydroxyindoleacetic acid levels and impulsive aggression or criminality.
Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects.
Central AVP may play a role in enhancing, while serotonin plays arole in inhibiting, aggressive behavior in personality-disordered individuals, in addition to the possibility of central AVP and serotonin interacting to influence human aggression.
Neurobiological correlates of borderline personality disorder.
The biological, psychological, and clinical findings in borderline personality disorder are integrated and four core elements are suggested to play a major role in the development of BPD: interpersonal stress, affective instability, impulsivity, and dissociation and self-injurious behavior.
Serotonin, impulsivity, and alcohol use disorders in the older adolescent: a psychobiological study.
Adolescents with early-onset AUD are characterized by impulsivity and aggressivity compared with healthy peers but do not demonstrate the diminished prolactin or cortisol responses to FEN characteristic of adult alcoholics with impulsive-aggression.
Fluoxetine and impulsive aggressive behavior in personality-disordered subjects.
Fluoxetine treatment has an antiaggressive effect on impulsive aggressive individuals with DSM-III-R personality disorder.
The adolescent brain and age-related behavioral manifestations
  • L. Spear
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2000