Developmental programming of CpG island methylation profiles in the human genome

@article{Straussman2009DevelopmentalPO,
  title={Developmental programming of CpG island methylation profiles in the human genome},
  author={Ravid Straussman and D. Nejman and D. Roberts and I. Steinfeld and B. Blum and N. Benvenisty and I. Simon and Z. Yakhini and H. Cedar},
  journal={Nature Structural &Molecular Biology},
  year={2009},
  volume={16},
  pages={564-571}
}
CpG island–like sequences are commonly thought to provide the sole signals for designating constitutively unmethylated regions in the genome, thus generating open chromatin domains within a sea of global repression. Using a new database obtained from comprehensive microarray analysis, we show that unmethylated regions (UMRs) seem to be formed during early embryogenesis, not as a result of CpG-ness, but rather through the recognition of specific sequence motifs closely associated with… Expand
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