Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep.

@article{VeigaLopez2013DevelopmentalPI,
  title={Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep.},
  author={Almudena Veiga-Lopez and Jacob Moeller and Divyen H. Patel and Wen Ye and Anthony P. Pease and Jennifer Kinns and Vasantha Padmanabhan},
  journal={Endocrinology},
  year={2013},
  volume={154 5},
  pages={
          1731-42
        }
}
Prenatal T excess causes reproductive and metabolic disruptions including insulin resistance, attributes of women with polycystic ovary syndrome. This study tested whether increases in visceral adiposity, adipocyte size, and total free fatty acids underlie the insulin resistance seen in prenatal T-treated female sheep. At approximately 16 months of age, insulin resistance and adipose tissue partitioning were determined via hyperinsulinemic euglycemic clamp and computed tomography, respectively… CONTINUE READING

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