Developmental potential of human oocytes reconstructed by transferring somatic cell nuclei into polyspermic zygote cytoplasm.

@article{Fan2009DevelopmentalPO,
  title={Developmental potential of human oocytes reconstructed by transferring somatic cell nuclei into polyspermic zygote cytoplasm.},
  author={Yong Fan and Xinjie Chen and Yumei Luo and Xiaolin Chen and Shaoying Li and Yulin Huang and Xiaofang Sun},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={382 1},
  pages={119-23}
}
The generation of patient-specific nuclear transfer embryonic stem cells holds huge promise in modern regenerative medicine and cell-based drug discovery. Since human in vivo matured oocytes are not readily available, human therapeutic cloning is developing slowly. Here, we investigated for the first time whether human polyspermic zygotes could support preimplantation development of cloned embryos. Our results showed that polyspermic zygotes could be used as recipients for human somatic cell… CONTINUE READING