Developmental potential and behavior of tetraploid cells in the mouse embryo.

@article{Eakin2005DevelopmentalPA,
  title={Developmental potential and behavior of tetraploid cells in the mouse embryo.},
  author={Guy S Eakin and Anna-Katerina Hadjantonakis and Virginia E Papaioannou and Richard R. Behringer},
  journal={Developmental biology},
  year={2005},
  volume={288 1},
  pages={150-9}
}
Tetraploid (4n) mouse embryos die at variable developmental stages. By examining 4n embryos from F2 hybrid and outbred mice, we show that 4n developmental potential is influenced by genetic background. The imprinted inactivation of an X chromosome-linked eGFP transgene in extraembryonic tissues occurred correctly in 4n embryos. A decrease of the cleavage rate in 4n preimplantation embryos compared to diploid (2n) embryos was revealed by real-time imaging, using a histone H2b:eGFP reporter. It… CONTINUE READING

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