Developmental plasticity of Foxp3+ regulatory T cells.

  title={Developmental plasticity of Foxp3+ regulatory T cells.},
  author={Shohei Hori},
  journal={Current opinion in immunology},
  volume={22 5},
Foxp3(+) regulatory T (Treg) cells constitute a distinct lineage of T lymphocytes committed to suppressive functions, thereby ensuring the robustness of self-tolerance and immune homeostasis in a changing environment. Recent studies have challenged this notion by suggesting that they retain developmental plasticity to convert to Foxp3(-) helper T (Th) cells in response to environmental perturbations such as inflammation and lymphopenia. However, this issue of Treg cell plasticity remains… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…