Developmental plasticity of Foxp3+ regulatory T cells.

@article{Hori2010DevelopmentalPO,
  title={Developmental plasticity of Foxp3+ regulatory T cells.},
  author={Shohei Hori},
  journal={Current opinion in immunology},
  year={2010},
  volume={22 5},
  pages={575-82}
}
Foxp3(+) regulatory T (Treg) cells constitute a distinct lineage of T lymphocytes committed to suppressive functions, thereby ensuring the robustness of self-tolerance and immune homeostasis in a changing environment. Recent studies have challenged this notion by suggesting that they retain developmental plasticity to convert to Foxp3(-) helper T (Th) cells in response to environmental perturbations such as inflammation and lymphopenia. However, this issue of Treg cell plasticity remains… CONTINUE READING

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