Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance.


AIMS AND OBJECTIVES To illustrate the complex interaction between ontogeny, i.e., age-dependent maturation, genetic polymorphisms and renal elimination clearance during infancy, based on developmental disposition of intravenous tramadol during infancy. BACKGROUND Tramadol (M) is metabolized by O-demethylation (cytochrome P450 [CYP] 2D6) to the… (More)
DOI: 10.1111/j.1460-9592.2010.03389.x


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