Developmental pharmacokinetics of lamivudine in 580 pediatric patients ranging from neonates to adolescents.

@article{Bouazza2011DevelopmentalPO,
  title={Developmental pharmacokinetics of lamivudine in 580 pediatric patients ranging from neonates to adolescents.},
  author={N. Ben Bouazza and D{\'e}borah Hirt and St{\'e}phane Blanche and Pierre Frange and Elisabeth Rey and J. -M. Treluyer and Sa{\"i}k Urien},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 7},
  pages={3498-504}
}
Lamivudine concentration-time courses were described for a very large range of ages to study the effects of body weight and maturation on lamivudine pharmacokinetics and to check the consistency of dosing recommendations. Lamivudine concentrations were monitored on a routine basis to produce concentrations similar to the known values in adults. Concentrations were measured in 580 children from 2 days to 18 years old. A total of 2,106 plasma lamivudine concentrations were measured, and a… CONTINUE READING