Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors.

@article{Rutenberg2006DevelopmentalPO,
  title={Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors.},
  author={Joshua B Rutenberg and Andreas Fischer and Haibo Jia and Manfred Gessler and Tao P. Zhong and M. Mercola},
  journal={Development},
  year={2006},
  volume={133 21},
  pages={4381-90}
}
Mutations in Notch2, Jagged1 or homologs of the Hairy-related transcriptional repressor Hey2 cause congenital malformations involving the non-chamber atrioventricular canal (AVC) and inner curvature (IC) regions of the heart, but the underlying mechanisms have not been investigated. By manipulating signaling directly within the developing chick heart, we demonstrated that Notch2, Hey1 and Hey2 initiate a signaling cascade that delimits the non-chamber AVC and IC regions. Specifically… CONTINUE READING