Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.

@article{Bertrand2012DevelopmentalPI,
  title={Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.},
  author={Fred E. Bertrand and Cameron Angus and William J Partis and George Sigounas},
  journal={Cell cycle},
  year={2012},
  volume={11 23},
  pages={4344-51}
}
A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

Similar Papers

Loading similar papers…