Developmental outcome after exposure to cyclooxygenase inhibitors during pregnancy and lactation.

  title={Developmental outcome after exposure to cyclooxygenase inhibitors during pregnancy and lactation.},
  author={Franciszek Burdan and Malgorzata Pliszczynska-Steuden and Ingrid Rozylo-Kalinowska and Anna Chalas and T Katarzyna Rozylo and Elżbieta Staroslawska and Robert Klepacz and Justyna Szumilo},
  journal={Reproductive toxicology},
  volume={32 4},
The developmental toxicity of non-selective (ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitors (DFU) was evaluated in rats. Compounds were administered separately from the eighth gestational to the seventh lactational day. After spontaneous delivery, the weight, length and number of fetuses were determined. The digital radiography and double-staining were used to evaluate the skeleton morphology and mineralization in 7-day-old pups. Maternal toxicity was also assessed… CONTINUE READING


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