Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms.

@article{Wadhwa2009DevelopmentalOO,
  title={Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms.},
  author={Pathik D. Wadhwa and Claudia Buss and Sonja Entringer and James M. Swanson},
  journal={Seminars in reproductive medicine},
  year={2009},
  volume={27 5},
  pages={358-68}
}
"Barker's hypothesis" emerged almost 25 years ago from epidemiological studies of birth and death records that revealed a high geographic correlation between rates of infant mortality and certain classes of later adult deaths as well as an association between birthweight and rates of adult death from ischemic heart disease. These observations led to a theory that undernutrition during gestation was an important early origin of adult cardiac and metabolic disorders due to fetal programming that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS
141 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 141 extracted citations

Similar Papers

Loading similar papers…