Developmental origin of wiring specificity in the olfactory system of Drosophila.

Abstract

In both insects and mammals, olfactory receptor neurons (ORNs) expressing specific olfactory receptors converge their axons onto specific glomeruli, creating a spatial map in the brain. We have previously shown that second order projection neurons (PNs) in Drosophila are prespecified by lineage and birth order to send their dendrites to one of approximately 50 glomeruli in the antennal lobe. How can a given class of ORN axons match up with a given class of PN dendrites? Here, we examine the cellular and developmental events that lead to this wiring specificity. We find that, before ORN axon arrival, PN dendrites have already created a prototypic map that resembles the adult glomerular map, by virtue of their selective dendritic localization. Positional cues that create this prototypic dendritic map do not appear to be either from the residual larval olfactory system or from glial processes within the antennal lobe. We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites.

7 Figures and Tables

050100'04'06'08'10'12'14'16
Citations per Year

593 Citations

Semantic Scholar estimates that this publication has 593 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Jefferis2004DevelopmentalOO, title={Developmental origin of wiring specificity in the olfactory system of Drosophila.}, author={Gregory S . X . E . Jefferis and Raj M Vyas and Daniela Berdnik and Ariane Ramaekers and Reinhard Stocker and Nobuaki K Tanaka and Kei Ito and Liqun Luo}, journal={Development}, year={2004}, volume={131 1}, pages={117-30} }