Developmental origin of preBötzinger complex respiratory neurons.

  title={Developmental origin of preB{\"o}tzinger complex respiratory neurons.},
  author={Paul A. Gray and John A Hayes and Guang Y Ling and Isabel R Llona and Srinivasan Tupal and Maria Cristina D Picardo and Sarah E Ross and Tsutomu Hirata and Joshua G Corbin and Jaime Eugen{\'i}n and Christopher A Del Negro},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 44},
A subset of preBötzinger Complex (preBötC) neurokinin 1 receptor (NK1R) and somatostatin peptide (SST)-expressing neurons are necessary for breathing in adult rats, in vivo. Their developmental origins and relationship to other preBötC glutamatergic neurons are unknown. Here we show, in mice, that the "core" of preBötC SST(+)/NK1R(+)/SST 2a receptor(+) (SST2aR) neurons, are derived from Dbx1-expressing progenitors. We also show that Dbx1-derived neurons heterogeneously coexpress NK1R and SST2aR… CONTINUE READING


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