Developmental neurotoxicity of ketamine in pediatric clinical use.

  title={Developmental neurotoxicity of ketamine in pediatric clinical use.},
  author={C Dong and Kanwaljeet J S Anand},
  journal={Toxicology letters},
  volume={220 1},
Ketamine is widely used as an anesthetic, analgesic, and sedative in pediatric clinical practice and it is also listed as an illicit drug by most countries. Recent in vivo and in vitro animal studies have confirmed that ketamine can induce neuronal cell death in the immature brain, resulting from widespread neuronal apoptosis. These effects can disturb normal development further altering the structure and functions of the brain. Our recent studies further indicate that ketamine can alter… CONTINUE READING