Developmental neurotoxicity of ethanol: in vitro inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in brain from neonatal but not adult rats.

@article{Balduini1990DevelopmentalNO,
  title={Developmental neurotoxicity of ethanol: in vitro inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in brain from neonatal but not adult rats.},
  author={Walter Balduini and Lucio Guido Costa},
  journal={Brain research},
  year={1990},
  volume={512 2},
  pages={248-52}
}
The in vitro effects of ethanol (EtOH) on muscarinic receptor-stimulated phosphoinositide metabolism were measured in cerebral cortex slices of adult and 7-day-old rats. EtOH (500 mM) caused a significant decrease (32-43%) of maximal accumulation of [3H]inositol phosphates (InsPs) induced by carbachol, and a 2-fold increase in its EC50 in 7-day-old rats, but had no effect in adult rats. The effect of EtOH on [3H]InsPs accumulation in neonatal rats was significant at a concentration as low as… CONTINUE READING

Similar Papers

Loading similar papers…