Developmental neurobiology of childhood stress and trauma.

  title={Developmental neurobiology of childhood stress and trauma.},
  author={Martin H. Teicher and Susan Andersen and Ann Polcari and Carl M. Anderson and Carryl P Navalta},
  journal={The Psychiatric clinics of North America},
  volume={25 2},
  pages={397-426, vii-viii}
Severe early stress and maltreatment produces a cascade of events that have the potential to alter brain development. The first stage of the cascade involves the stress-induced programming of the glucocorticoid, noradrenergic, and vasopressin-oxytocin stress response systems to augment stress responses. These neurohumors then produce effects on neurogenesis, synaptic overproduction and pruning, and myelination during specific sensitive periods. Major consequences include reduced size of the mid… CONTINUE READING
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