Developmental modulation of nonhomologous end joining in Caenorhabditis elegans.

  title={Developmental modulation of nonhomologous end joining in Caenorhabditis elegans.},
  author={Iuval Clejan and Julie Boerckel and Shawn Ahmed},
  volume={173 3},
Homologous recombination and nonhomologous end joining (NHEJ) are important DNA double-strand break repair pathways in many organisms. C. elegans strains harboring mutations in the cku-70, cku-80, or lig-4 NHEJ genes displayed multiple developmental abnormalities in response to radiation-induced DNA damage in noncycling somatic cells. These phenotypes did not result from S-phase, DNA damage, or mitotic checkpoints, apoptosis, or stress response pathways that regulate dauer formation. However… CONTINUE READING
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