Developmental modulation of nonhomologous end joining in Caenorhabditis elegans.

@article{Clejan2006DevelopmentalMO,
  title={Developmental modulation of nonhomologous end joining in Caenorhabditis elegans.},
  author={Iuval Clejan and Julie Boerckel and Shawn Ahmed},
  journal={Genetics},
  year={2006},
  volume={173 3},
  pages={
          1301-17
        }
}
Homologous recombination and nonhomologous end joining (NHEJ) are important DNA double-strand break repair pathways in many organisms. C. elegans strains harboring mutations in the cku-70, cku-80, or lig-4 NHEJ genes displayed multiple developmental abnormalities in response to radiation-induced DNA damage in noncycling somatic cells. These phenotypes did not result from S-phase, DNA damage, or mitotic checkpoints, apoptosis, or stress response pathways that regulate dauer formation. However… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 75 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

76 Citations

051015'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 76 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-7 of 7 references

Molecular analysis of telomere fusions in Arabidopsis : multiple pathways for chromosome endjoining

J. G. W hite
EMBO J . • 2004

elegans homolog of the p 53 tumor suppressor is required for DNA damageinduced apoptosis

C. The
Curr . Biol . • 2001

elegans cell death gene ced3 encodes a protein similar to mammalian interleukin - 1 betaconverting enzyme

C. The
Cell • 1993