Developmental modulation of GABA(A) receptor function by RNA editing.

  title={Developmental modulation of GABA(A) receptor function by RNA editing.},
  author={Elizabeth Y. Rula and Andre H Lagrange and Michelle M Jacobs and Ningning Hu and Robert L Macdonald and Ronald B. Emeson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 24},
Adenosine-to-inosine (A-to-I) editing of RNA transcripts is an increasingly recognized cellular strategy to modulate the function of proteins involved in neuronal excitability. We have characterized the editing of transcripts encoding the alpha3 subunit of heteromeric GABA(A) receptors (Gabra3), in which a genomically encoded isoleucine codon (ATA) is converted to a methionine codon (ATI) in a region encoding the predicted third transmembrane domain of this subunit. Editing at this position (I… CONTINUE READING