Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice.

@article{Townsend2003DevelopmentalLO,
  title={Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice.},
  author={Matthew Townsend and Akira Yoshii and Masayoshi Mishina and Martha Constantine-Paton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 3},
  pages={1340-5}
}
The N-methyl-d-aspartate (NMDA) glutamate receptor (NMDAR), long implicated in developmental plasticity, shows decay time kinetics that shorten postnatally as NR2A subunits are added to the receptor. Neither the mechanism nor immediate effect of this change is known. We studied developing NMDAR currents by using visual neurons in slices from NR2A knockout (NR2AKO) and WT mice. Both strains show increased dendritic levels of synaptic density scaffolding protein PSD-95 with age. Dendritic levels… CONTINUE READING

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