Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2).

@article{OrrUrtreger1993DevelopmentalLO,
  title={Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2).},
  author={Avi Orr-Urtreger and Mark T Bedford and Tatyana Burakova and Esther Arman and Y Zimmer and Avner Yayon and David Givol and Peter Lonai},
  journal={Developmental biology},
  year={1993},
  volume={158 2},
  pages={475-86}
}
The gene for fibroblast growth factor receptor-2 (FGFR2) encodes two splice variants designated here as keratinocyte growth factor (KGFR) and bek. Their ligand-binding specificity is markedly different due to mutually exclusive alternative splicing. We asked whether alternative exon usage, in addition to influencing receptor specificity, could be correlated with transcriptional localization. This problem was studied by in situ hybridization and PCR, using probes and primers specific for the… CONTINUE READING
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