Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.

@article{Yoshimoto2015DevelopmentalII,
  title={Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.},
  author={Ryo Yoshimoto and Shinnichi Iwasaki and Hideki Takago and Tatsuo Nakajima and Yoshinori Sahara and Kouichi Kitamura},
  journal={Neuroscience},
  year={2015},
  volume={284},
  pages={632-42}
}
The primary vestibular neurons convey afferent information from hair cells in the inner ear to the vestibular nuclei and the cerebellum. The intrinsic firing properties of vestibular ganglion cells (VGCs) are heterogeneous to sustained membrane depolarization, and undergo marked developmental changes from phasic to tonic types during the early postnatal period. Previous studies have shown that low-voltage-activated potassium channels, Kv1 and Kv7, play a critical role in determining the firing… CONTINUE READING
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