Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.

@article{Fujiwara2010DevelopmentalHA,
  title={Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.},
  author={Ryoichi Fujiwara and Nghia D. Nguyen and Shujuan Chen and Robert H. Tukey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 11},
  pages={5024-9}
}
High levels of unconjugated bilirubin (UCB) in newborn children is associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can lead to CNS toxicity, brain damage, and even death. Little is known regarding those events that lead to UCB accumulation in brain tissue, and therefore, we sought to duplicate this condition in mice. The human UGT1 locus, encoding all 9-UGT1A genes including UGT1A1, was expressed in Ugt1(-/-) mice. Because the most common clinical… CONTINUE READING

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