Developmental genetics of vertebrate glial–cell specification

  title={Developmental genetics of vertebrate glial–cell specification},
  author={D. Rowitch and A. Kriegstein},
  • D. Rowitch, A. Kriegstein
  • Published 2010
  • Biology, Medicine
  • Nature
  • Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regulate the development of the diverse neuron types. The switch from producing neuronal to glial subtype-specific precursors can be modelled as an interplay between region-restricted… CONTINUE READING
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