Developmental genetics of vertebrate glial–cell specification

@article{Rowitch2010DevelopmentalGO,
  title={Developmental genetics of vertebrate glial–cell specification},
  author={David H. Rowitch and Arnold R. Kriegstein},
  journal={Nature},
  year={2010},
  volume={468},
  pages={214-222}
}
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regulate the development of the diverse neuron types. The switch from producing neuronal to glial subtype-specific precursors can be modelled as an interplay between region-restricted… 
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This chapter will provide an assessment of data currently available from in vivo and in vitro studies evaluating the dynamic, interactive nature of these processes throughout the progression of nervous system development.
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Studies of temporal-identity specification and progenitor competence can provide insight into how neural progenitors could be used to more effectively generate specific cell types for brain repair.
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The regulation and the role of the fly glial determinant are described and the impact of the determinant in cell plasticity and differentiation is discussed and the conservation of this pathway across evolution is addressed.
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