Developmental genetics of vertebrate glial–cell specification

@article{Rowitch2010DevelopmentalGO,
  title={Developmental genetics of vertebrate glial–cell specification},
  author={David H. Rowitch and Arnold R. Kriegstein},
  journal={Nature},
  year={2010},
  volume={468},
  pages={214-222}
}
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regulate the development of the diverse neuron types. The switch from producing neuronal to glial subtype-specific precursors can be modelled as an interplay between region-restricted… 
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539 Citations

Oligodendrocyte generation during mouse development
TLDR
Advances in the research on OL development are reviewed and areas where questions remain to be answered in both developmental biology and neurobiology related aspects are highlighted.
Genetic approaches to study glial cells in the rodent brain
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Techniques that allow for cell‐specific gene modification including targeted mutagenesis and viral transduction are summarized and genetic models that allow to target the main glial cell types in the central nervous system are described.
Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders
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Recent studies that explore glial functions in normal neuronal development, along with Drosophila models that seek to identify the pathological implications of glial defects in the context of various central nervous system disorders are reviewed.
Astrocyte development and heterogeneity.
TLDR
It is proposed that astrocytes' diversity will provide fundamental clues to understand regional brain organization and function and could help explain how the central nervous system retains embryonic positional information into adulthood.
Physiology of Astroglia.
TLDR
Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Mechanisms regulating the development of oligodendrocytes and central nervous system myelin
Developmental Vascularization, Neurogenesis, Myelination, and Astrogliogenesis
TLDR
This chapter will provide an assessment of data currently available from in vivo and in vitro studies evaluating the dynamic, interactive nature of these processes throughout the progression of nervous system development.
Temporal fate specification and neural progenitor competence during development
TLDR
Studies of temporal-identity specification and progenitor competence can provide insight into how neural progenitors could be used to more effectively generate specific cell types for brain repair.
Specification, plasticity and evolutionary origin of peripheral glial cells
Lineage specification in the fly nervous system and evolutionary implications
TLDR
The regulation and the role of the fly glial determinant are described and the impact of the determinant in cell plasticity and differentiation is discussed and the conservation of this pathway across evolution is addressed.
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