Developmental gene expression of gastrin receptor in rat stomach.


Gastrin, which is present in fetal plasma, may have important roles in the development of gastric mucosa, since it is not only a potent stimulator of gastric acid secretion but also a growth promoting factor. Gastrin regulates various cellular functions via its receptors on cell membrane. Therefore, in order to elucidate a role for gastrin in the development of gastrointestinal system during gestation, Northern blot analysis was performed. The results of the study suggested that gastrin receptor is mainly present on parietal cells. Furthermore, proton pump and gastrin receptor gene expressions in parietal cells were strongly stimulated by the administration of exogenous gastrin. In conclusion, gastrin may be involved in the developmental change of parietal cells through its receptors.

Cite this paper

@article{Wang1997DevelopmentalGE, title={Developmental gene expression of gastrin receptor in rat stomach.}, author={H Y Wang and Yoshikazu Kinoshita and Mohamat Sabri Hassan and Yuko Matsushima and Hiroshi Fukui and Taira Maekawa and Akira Okada and Shinya Waki and Chiharu Kawanami and Kanta Kishi and Minoru Watanabe and Sakan Maeda and Tsutomu Chiba}, journal={Regulatory peptides}, year={1997}, volume={70 2-3}, pages={183-9} }