Developmental gene expression and immunohistochemical study of the human endocrine pancreas during fetal life.

@article{Sanchez1998DevelopmentalGE,
  title={Developmental gene expression and immunohistochemical study of the human endocrine pancreas during fetal life.},
  author={Didier Sanchez and Christine Moriscot and Sandra Marchand and Catherine Fredouille and Catherine Figarella and Odette Guy-Crotte},
  journal={Hormone research},
  year={1998},
  volume={50 5},
  pages={258-63}
}
The development of human endocrine pancreas has been the subject of many immunohistochemical studies but very little is known at the molecular level. We have determined the patterns of gene expression of glucagon, somatostatin and pancreatic polypeptide during fetal life (16-41 weeks of gestation) using the dot-blot hybridization method. In spite of some dispersion in the mRNA levels, no progressive increase or decrease during this period of fetal life could be found, as previously observed for… CONTINUE READING