Developmental functions of mammalian Hox genes.

  title={Developmental functions of mammalian Hox genes.},
  author={Beno{\^i}t Favier and Pascal Doll{\'e}},
  journal={Molecular human reproduction},
  volume={3 2},
The structure of the four murine Hox complexes and the co-ordinate expression patterns of Hox genes have been elucidated for almost a decade. However, clues about their developmental functions have been recently uncovered from the analysis of loss-of-function mutants generated by the gene targeting technique, as well as from transgenic mice with altered Hox gene expression domains. The 'anterior' Hox genes control the morphogenetic programme of specific hindbrain segments (rhombomeres) or… CONTINUE READING
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