Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring.

@article{Boulle2016DevelopmentalFE,
  title={Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring.},
  author={Fabien Boulle and Jodi Pawluski and Judith R Homberg and Barbie Machiels and Yvet Kroeze and Neha Kumar and Harry W. M. Steinbusch and Gunter R L Kenis and Daniel L A van den Hove},
  journal={Hormones and behavior},
  year={2016},
  volume={80},
  pages={47-57}
}
A growing number of infants are exposed to selective serotonin reuptake inhibitor (SSRI) medications during the perinatal period. Perinatal exposure to SSRI medications alter neuroplasticity and increase depressive- and anxiety-related behaviors, particularly in male offspring as little work has been done in female offspring to date. The long-term effects of SSRI on development can also differ with previous exposure to prenatal stress, a model of maternal depression. Because of the limited work… CONTINUE READING
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