Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.

  title={Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.},
  author={Leah Jaffe and Elizabeth J. Robertson and Elizabeth K. Bikoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 13},
The absence of expression of class I products of the major histocompatibility complex at early stages of development is thought to play a key role in maternal tolerance of the fetal allograft. To test this, we developed a strategy that would allow us to describe the consequences of overexpression of the H-2Dd transplantation antigen in the developing embryo. A construct containing the H-2Dd gene under control of the human beta-actin promoter was transfected into pluripotent embryonic stem (ES… Expand
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Embryonic stem cells and potency to induce transplantation tolerance
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  • Biology, Medicine
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  • 2003
Most recent data indicate the potential of embryonic stem cells (ESC) to offer a possible solution for low risk induction of multilineage mixed chimaerism and tolerance not involving any immunosuppression, due to their unique property of low immunogenicity and high plasticity. Expand
Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif.
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