Developmental expression of the vav protooncogene.

  title={Developmental expression of the vav protooncogene.},
  author={Xos{\'e} R Bustelo and Steven Rubin and K L Suen and Daniel Alfredo Hern{\'a}ndez Carrasco and Mariano Barbacid},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  volume={4 4},
We have examined the expression of the vav protooncogene during mouse embryogenesis using RNase protection assays, in situ hybridization, and immunocytochemical analysis. vav gene transcripts were first detected in E11.5 embryos in the blood-forming islands and megakaryocytes of the fetal liver. During diversification of hematopoietic activity in the embryo, vav gene expression became down-regulated in the liver and activated in thymus and spleen. In newborn animals, vav expression was also… CONTINUE READING


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