Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology.

@article{Shiota2006DevelopmentalEO,
  title={Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology.},
  author={Jun Shiota and Mitsuru Ishikawa and Hiroyuki Sakagami and Masaaki Tsuda and Jay M Baraban and Akiko Tabuchi},
  journal={Journal of neurochemistry},
  year={2006},
  volume={98 6},
  pages={1778-88}
}
The dynamic changes in dendritic morphology displayed by developing and mature neurons have stimulated interest in deciphering the signaling pathways involved. Recent studies have identified megakaryocytic acute leukemia (MAL), a serum response factor (SRF) co-activator, as a key component of a signaling pathway linking changes in the actin cytoskeleton to SRF-mediated transcription. To help define the role of this pathway in regulating dendritic morphology, we have characterized the pattern of… CONTINUE READING