Developmental expression of the SRF co‐activator MAL in brain: role in regulating dendritic morphology

@article{Shiota2006DevelopmentalEO,
  title={Developmental expression of the SRF co‐activator MAL in brain: role in regulating dendritic morphology},
  author={Jun Shiota and Mitsuru Ishikawa and Hiroyuki Sakagami and Masaaki Tsuda and Jay M. Baraban and Akiko Tabuchi},
  journal={Journal of Neurochemistry},
  year={2006},
  volume={98}
}
The dynamic changes in dendritic morphology displayed by developing and mature neurons have stimulated interest in deciphering the signaling pathways involved. Recent studies have identified megakaryocytic acute leukemia (MAL), a serum response factor (SRF) co‐activator, as a key component of a signaling pathway linking changes in the actin cytoskeleton to SRF‐mediated transcription. To help define the role of this pathway in regulating dendritic morphology, we have characterized the pattern of… 
Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF
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TLDR
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TLDR
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TLDR
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TLDR
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Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons
TLDR
The findings suggest that the subcellular localization of MKL1 isoforms, which is mediated by the number of actin-binding RPEL motifs, regulates their effect on SRF-mediated gene expression and dendritic morphology.
Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development
TLDR
The MRTF/Srf partnership interlinks two key signaling pathways that control actin treadmilling and neuronal maturation, thereby fulfilling a regulatory loop that couples cytoskeletal dynamics to nuclear gene transcription during brain development.
Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons.
MKLs: co-factors of serum response factor (SRF) in neuronal responses.
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References

SHOWING 1-10 OF 24 REFERENCES
Nuclear translocation of the SRF co‐activator MAL in cortical neurons: role of RhoA signalling
TLDR
Findings demonstrate that RhoA signaling pathways are able to regulate transcription in neurons by triggering translocation of the SRF co‐activator MAL.
SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability
TLDR
It is shown that deletion of serum response factor in specific neuronal populations in adult mice results in profound deficits in activity-dependent immediate early gene expression, but components of upstream signaling pathways and cyclic AMP–response element binding protein (CREB)-dependent transactivation remain intact.
Neuronal migration in the murine rostral migratory stream requires serum response factor
TLDR
It is reported that SRF-controlled gene expression directs both the structure and dynamics of the actin microfilament, thereby determining cell-autonomous neuronal migration in the mouse forebrain.
Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons
TLDR
Results indicate that Tech regulates RhoA signaling pathways in developing and mature forebrain neurons, as Tech protein levels increase during post‐natal development and remain at peak levels into adulthood.
Serum response factor controls neuronal circuit assembly in the hippocampus
Higher organisms rely on multiple modes of memory storage using the hippocampal network, which is built by precisely orchestrated mechanisms of axonal outgrowth, guidance and synaptic targeting. We
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
TLDR
The results show that two mature miRNAs, derived from the same miRNA polycistron and transcribed together, can carry out distinct biological functions and suggest a molecular mechanism in which miRN as participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development.
Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
TLDR
It is suggested that a subset of immediate early and SRF target genes are activated by the Rho-MKL pathway, possibly due to other activation mechanisms such as MAPK phosphorylation of TCFs.
Myocardin/MKL family of SRF coactivators: Key regulators of immediate early and muscle specific gene expression
TLDR
The regulation of this coactivator family is key to understanding how SRF target genes are activated during muscle cell differentiation or growth factor induced cell proliferation.
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