Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.

@article{Asayesh2005DevelopmentalEO,
  title={Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.},
  author={Amir Asayesh and Tomas Alanentalo and Nelson K. S. Khoo and Ulf Ahlgren},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2005},
  volume={232 4},
  pages={1105-14}
}
The A Disintegrin And Metalloprotease (ADAM) family of metalloproteases affects a variety of proteins with important roles in development and disease, including growth factors and adhesion molecules. We have analyzed the expression patterns of ADAMs 9, 10, and 17 during pancreas ontogeny. All ADAMs investigated were expressed in the pancreatic anlagen but invariably became restricted to divergent pancreatic compartments. ADAM9 and 17 became restricted to the insulin-producing beta-cells and all… CONTINUE READING

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