Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues.

@article{Myllynen2009DevelopmentalEO,
  title={Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues.},
  author={P{\"a}ivi K. Myllynen and Elina Immonen and Maria Kummu and Kirsi V{\"a}h{\"a}kangas},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2009},
  volume={5 12},
  pages={1483-99}
}
Transporter proteins and xenobiotic metabolizing enzymes have a crucial role in the fate of xenobiotics in human body. The expression in human placenta and fetal tissues of the proteins most commonly participating in pharmaco/toxicokinetics is reviewed. In case human data are not available, relevant animal data are included. Among transporter proteins ABC transporters, monoamine transporters and organic anion transporters are pharmacologically and toxicologically of main interest. From… CONTINUE READING

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