Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain.

@article{Jantzie2015DevelopmentalEO,
  title={Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain.},
  author={Lauren L Jantzie and Delia Talos and Michele C. Jackson and H S Park and Dionne A. Graham and Mirna Lechpammer and Rebecca D. Folkerth and Joseph J. Volpe and Frances E. Jensen},
  journal={Cerebral cortex},
  year={2015},
  volume={25 2},
  pages={482-95}
}
The pathophysiology of perinatal brain injury is multifactorial and involves hypoxia-ischemia (HI) and inflammation. N-methyl-d-aspartate receptors (NMDAR) are present on neurons and glia in immature rodents, and NMDAR antagonists are protective in HI models. To enhance clinical translation of rodent data, we examined protein expression of 6 NMDAR subunits in postmortem human brains without injury from 20 postconceptional weeks through adulthood and in cases of periventricular leukomalacia (PVL… CONTINUE READING