Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome.

@article{Pacey2007DevelopmentalEO,
  title={Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome.},
  author={Laura K. Pacey and Laurie C. Doering},
  journal={Glia},
  year={2007},
  volume={55 15},
  pages={1601-9}
}
One of the most common causes of mental retardation in humans, Fragile X syndrome, results from the absence of FMRP, the protein product of the FMR1 gene. In the nervous system, expression of FMRP has been thought to be confined mainly to neurons as little research has examined FMRP expression in non-neuronal lineages. We present evidence that, in addition to neuronal expression, FMRP is expressed in developing CNS glial cells in vitro and in vivo. The neurosphere assay was used to establish… CONTINUE READING
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