Developmental expression of Bcl-2 protein in human cortex.

  title={Developmental expression of Bcl-2 protein in human cortex.},
  author={Lars Fredrik Jarskog and John H. Gilmore},
  journal={Brain research. Developmental brain research},
  volume={119 2},
Apoptosis is essential for normal human neurodevelopment and is increasingly recognized for its role in various neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Bcl-2 is a 26 kDa membrane-associated protein known to protect neurons against apoptosis. Interestingly, Bcl-2 protein levels are altered in certain neurodegenerative disorders that reveal increased apoptosis. However, little is known about the normal expression of Bcl-2 protein in human brain. Bcl-2 protein… CONTINUE READING


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