Developmental expression and organisation of fibrinogen genes in the zebrafish.

  title={Developmental expression and organisation of fibrinogen genes in the zebrafish.},
  author={R J Fish and Silja Vorjohann and Fr{\'e}d{\'e}rique B{\'e}na and Alexandre Fort and M Neerman-Arbez},
  journal={Thrombosis and haemostasis},
  volume={107 1},
The zebrafish is a model organism for studying vertebrate development and many human diseases. Orthologues of the majority of human coagulation factors are present in zebrafish, including fibrinogen. As a first step towards using zebrafish to model human fibrinogen disorders, we cloned the zebrafish fibrinogen cDNAs and made in situ hybridisations and quantitative reverse transcription-polymerase chain reactions (qRT-PCR) to detect zebrafish fibrinogen mRNAs. Prior to liver development or blood… CONTINUE READING
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